{"id":1082,"date":"2021-05-23T00:29:28","date_gmt":"2021-05-23T00:29:28","guid":{"rendered":"https:\/\/derm.com.ua\/?p=1082"},"modified":"2024-10-14T08:07:33","modified_gmt":"2024-10-14T08:07:33","slug":"immunobiologic-therapy-for-psoriasis","status":"publish","type":"post","link":"https:\/\/www.derm.com.ua\/en\/psoriasis-us\/immunobiologic-therapy-for-psoriasis\/","title":{"rendered":"Immunobiologic therapy for psoriasis"},"content":{"rendered":"<p><strong><img decoding=\"async\" class=\"alignnone wp-image-109 size-full\" src=\"https:\/\/derm.com.ua\/wp-content\/uploads\/2020\/08\/78e4e172452febe6c2ade6d08ea61c3d7b151246.00000081.jpg\" alt=\"\" width=\"192\" height=\"141\" \/><\/strong><\/p>\n<h2><b>Immunobiological Therapy of Psoriasis and Stem Cell Treatment: A Complete Overview<\/b><\/h2>\n<p>Psoriasis is a chronic inflammatory skin disease that affects millions of people around the world. Characterized by the formation of red, flaky plaques on the skin, psoriasis can significantly impair the patient&#8217;s quality of life. This disease is associated with immune system dysfunction, which leads to excessive skin cell growth and inflammation. In recent decades, many new treatments have emerged, including immunobiological and stem cell therapies. In this article, we will take a closer look at the available drugs for psoriasis treatment in Ukraine and stem cell therapy options, as well as delve into the mechanisms of action of these methods and their effectiveness.<\/p>\n<p><img fetchpriority=\"high\" decoding=\"async\" class=\"alignnone size-medium wp-image-2339\" src=\"https:\/\/derm.com.ua\/wp-content\/uploads\/2021\/05\/2-300x171.jpg\" sizes=\"(max-width: 300px) 100vw, 300px\" srcset=\"https:\/\/derm.com.ua\/wp-content\/uploads\/2021\/05\/2-300x171.jpg 300w, https:\/\/derm.com.ua\/wp-content\/uploads\/2021\/05\/2-768x439.jpg 768w, https:\/\/derm.com.ua\/wp-content\/uploads\/2021\/05\/2.jpg 919w\" alt=\"\u0406\u043c\u0443\u043d\u043e\u0431\u0456\u043e\u043b\u043e\u0433\u0456\u0447\u043d\u0430 \u0422\u0435\u0440\u0430\u043f\u0456\u044f \u041f\u0441\u043e\u0440\u0456\u0430\u0437\u0443 \u0444\u043e\u0442\u043e\" width=\"300\" height=\"171\" \/><\/p>\n<h3><b>Definition and epidemiology<\/b><\/h3>\n<p>Psoriasis is an autoimmune disease that can manifest itself in various forms. It is often relapsing and can develop at any age, although it most often occurs in people aged 15 to 35. According to the WHO, psoriasis affects about 2-3% of the world&#8217;s population, making it one of the most common dermatological pathologies.<\/p>\n<h3><b>Causes of psoriasis<\/b><\/h3>\n<p>Psoriasis is considered a multifactorial disease, meaning that both genetic and environmental factors influence its development. The main causes include:<\/p>\n<ul>\n<li aria-level=\"1\">Genetic predisposition: the presence of psoriasis in close relatives increases the risk of developing it.<\/li>\n<li aria-level=\"1\">Immune disorders: an abnormal reaction of the immune system to external and internal factors leads to inflammation.<\/li>\n<li aria-level=\"1\">Environmental factors: stress, infectious diseases, skin injuries, alcohol consumption, and smoking can trigger an exacerbation of the disease.<\/li>\n<\/ul>\n<p>Psoriasis occurs as a result of an improper reaction of the human immune system to environmental factors. The process of inflammation development in psoriasis is a complex set of immunological reactions. A key role in psoriasis lesions is played by a protein called tumor necrosis factor alpha (TNF-alpha), which is produced by immune system cells, and its amount increases dramatically in psoriasis. The most modern treatment option for psoriasis, as well as a number of other immunoinflammatory diseases, is immunobiological therapy.<\/p>\n<p><img decoding=\"async\" class=\"alignnone size-medium wp-image-2336\" src=\"https:\/\/derm.com.ua\/wp-content\/uploads\/2021\/05\/1-300x171.jpg\" sizes=\"(max-width: 300px) 100vw, 300px\" srcset=\"https:\/\/derm.com.ua\/wp-content\/uploads\/2021\/05\/1-300x171.jpg 300w, https:\/\/derm.com.ua\/wp-content\/uploads\/2021\/05\/1-768x439.jpg 768w, https:\/\/derm.com.ua\/wp-content\/uploads\/2021\/05\/1.jpg 919w\" alt=\"\u0406\u043c\u0443\u043d\u043e\u0431\u0456\u043e\u043b\u043e\u0433\u0456\u0447\u043d\u0430 \u0422\u0435\u0440\u0430\u043f\u0456\u044f \u041f\u0441\u043e\u0440\u0456\u0430\u0437\u0443\" width=\"300\" height=\"171\" \/><\/p>\n<h3><b>Symptoms and forms<\/b><\/h3>\n<p>Symptoms of psoriasis can vary depending on its form. The most common forms include:<\/p>\n<ul>\n<li aria-level=\"1\">Psoriasis in the plaques: characterized by the formation of bright red plaques that flake off and are covered with silvery scales.<\/li>\n<li aria-level=\"1\">Nesting psoriasis: manifests itself in the form of small plaques, most often on the trunk and extremities.<\/li>\n<li aria-level=\"1\">Psoriatic arthritis: joint inflammation that can accompany psoriasis.<\/li>\n<\/ul>\n<p>The main symptoms include itching, burning, pain, and changes in the nails and joints.<\/p>\n<h2>Traditional methods of treating psoriasis<\/h2>\n<p>Treating psoriasis can be a complex and multi-stage process. Depending on the severity of the disease and the patient&#8217;s characteristics, the doctor may recommend different methods.<\/p>\n<h3><b>Topical medications<\/b><\/h3>\n<p>Topical medications are used to treat mild to moderate psoriasis. They are applied directly to the affected areas of the skin and help reduce inflammation and itching.<\/p>\n<ul>\n<li aria-level=\"1\">Corticosteroids: These are the most commonly used topical medications. They help reduce inflammation and itching, but can cause side effects if used for too long.<\/li>\n<li aria-level=\"1\">Vitamin D3: preparations containing the active form of vitamin D help to slow the growth of skin cells and improve the condition of plaques.<\/li>\n<li aria-level=\"1\">Retinoids: Vitamin A-based products that normalize cell division and reduce inflammation.<\/li>\n<li aria-level=\"1\">Salicylic acid: helps to remove scales and relieve inflammation. Often used in combination with other topical agents.<\/li>\n<\/ul>\n<h3><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-2342 size-medium\" src=\"https:\/\/derm.com.ua\/wp-content\/uploads\/2021\/05\/3-300x171.jpg\" sizes=\"(max-width: 300px) 100vw, 300px\" srcset=\"https:\/\/derm.com.ua\/wp-content\/uploads\/2021\/05\/3-300x171.jpg 300w, https:\/\/derm.com.ua\/wp-content\/uploads\/2021\/05\/3-768x439.jpg 768w, https:\/\/derm.com.ua\/wp-content\/uploads\/2021\/05\/3.jpg 919w\" alt=\"\u0444\u043e\u0440\u043c\u0438 \u043f\u0441\u043e\u0440\u0456\u0430\u0437\u0443\" width=\"300\" height=\"171\" \/><\/h3>\n<h3>Systemic medications<\/h3>\n<p>In severe psoriasis, your doctor may prescribe systemic medications that affect the entire body. These medications can have serious side effects and require careful monitoring.<\/p>\n<ul>\n<li aria-level=\"1\">Methotrexate: reduces the activity of the immune system and slows down the division of skin cells. It is usually prescribed for severe psoriasis.<\/li>\n<li aria-level=\"1\">Cyclosporine: an immunosuppressant that helps control inflammation. It is effective but can cause a number of side effects.<\/li>\n<li aria-level=\"1\">Acitretin: A systemic retinoid used to treat severe psoriasis. It helps to normalize skin cell growth and reduce inflammation.<\/li>\n<\/ul>\n<h3><strong>Immunobiological drugs<\/strong><\/h3>\n<p>Immunobiological therapy is a modern method of treating psoriasis, which involves the use of drugs aimed at blocking specific molecules involved in inflammatory processes. In recent decades, with the development of molecular biology and immunology, it has become possible to create biological drugs with a narrowly targeted action that selectively affect certain mechanisms without affecting other components of the immune system. In psoriasis, an extremely effective mechanism is to reduce elevated levels of TNF-alpha by binding it to a specific artificially created antibody. With the elimination of TNF-alpha, the cascade of immunological reactions is broken and the process stops. Modern TNF-alpha inhibitors are well tolerated and easy to use.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-2345 size-medium\" src=\"https:\/\/derm.com.ua\/wp-content\/uploads\/2021\/05\/4-300x171.jpg\" sizes=\"(max-width: 300px) 100vw, 300px\" srcset=\"https:\/\/derm.com.ua\/wp-content\/uploads\/2021\/05\/4-300x171.jpg 300w, https:\/\/derm.com.ua\/wp-content\/uploads\/2021\/05\/4-768x439.jpg 768w, https:\/\/derm.com.ua\/wp-content\/uploads\/2021\/05\/4.jpg 919w\" alt=\"\u0406\u043c\u0443\u043d\u043e\u0431\u0456\u043e\u043b\u043e\u0433\u0456\u0447\u043d\u0430 \u0442\u0435\u0440\u0430\u043f\u0456\u044f - \u0446\u0435 \u0441\u0443\u0447\u0430\u0441\u043d\u0438\u0439 \u043c\u0435\u0442\u043e\u0434 \u043b\u0456\u043a\u0443\u0432\u0430\u043d\u043d\u044f \u043f\u0441\u043e\u0440\u0456\u0430\u0437\u0443\" width=\"300\" height=\"171\" \/><\/p>\n<p>Several immunobiological drugs are available in Ukraine.<\/p>\n<div class=\"flex max-w-full flex-col flex-grow AIPRM__conversation__response\">\n<div class=\"min-h-8 text-message flex w-full flex-col items-end gap-2 whitespace-normal break-words [.text-message+&amp;]:mt-5\" dir=\"auto\" data-message-model-slug=\"gpt-4o-mini\" data-message-id=\"15185010-61f0-468c-b88d-3ba5c9017b50\" data-message-author-role=\"assistant\">\n<div class=\"flex w-full flex-col gap-1 empty:hidden first:pt-[3px]\">\n<div class=\"markdown prose w-full break-words dark:prose-invert light\">\n<table>\n<thead>\n<tr>\n<th><strong>The drug<\/strong><\/th>\n<th><strong>The dosage<\/strong><\/th>\n<th><strong>Application<\/strong><\/th>\n<th><strong>Approximate price (UAH)<\/strong><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>Adalimumab<\/strong><\/td>\n<td>40 mg every 2 weeks (after the initial dose)<\/td>\n<td>Subcutaneous injection, indicated for moderate to severe psoriasis<\/td>\n<td>13,000 &#8211; 15,000 per package (2 vials)<\/td>\n<\/tr>\n<tr>\n<td><strong>Infliximab<\/strong><\/td>\n<td>5 mg\/kg (intravenous) on weeks 0, 2 and 6, then every 8 weeks<\/td>\n<td>Intravenous injection, effective in severe psoriasis<\/td>\n<td>18,000 &#8211; 22,000 per package (1 vial)<\/td>\n<\/tr>\n<tr>\n<td><strong>Ustekinumab<\/strong><\/td>\n<td>45 mg (initial dose), then 45 mg every 12 weeks<\/td>\n<td>Subcutaneous injection, indicated for moderate to severe psoriasis<\/td>\n<td>22,000 &#8211; 25,000 per package (1 vial)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3>Notes:<\/h3>\n<ul>\n<li>Prices may vary depending on the pharmacy and region.<\/li>\n<li>Before starting treatment, be sure to consult your doctor for individualized recommendations and to clarify the dosage.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"mb-2 flex gap-3 empty:hidden -ml-2\">\n<div class=\"items-center justify-start rounded-xl p-1 flex\"><\/div>\n<\/div>\n<h4><b>Preparation for treatment<\/b><\/h4>\n<p>Do I need to undergo any tests before starting treatment? Before starting treatment, you need to undergo a general and biochemical blood test, as well as a test for latent tuberculosis (X-ray, Mantoux test).<\/p>\n<p>This is important for assessing your general health and identifying contraindications to treatment.<\/p>\n<h3><strong>How immunobiological therapy for psoriasis works<\/strong><\/h3>\n<p>The drug is administered as a subcutaneous injection or intravenous infusion, and the dosage regimen depends on the specific drug and the patient&#8217;s condition. Treatment is carried out only under the supervision of a doctor who has experience in the use of immunobiological drugs. The doctors of our clinic have their own experience in the use of immunobiological drugs, regularly attend scientific events on the problem of psoriasis and always have the latest information about modern methods of treatment<\/p>\n<h2 id=\"h-\u043f\u0441\u043e\u0440\u0456\u0430\u0437-\u043b\u0456\u043a\u0443\u0432\u0430\u043d\u043d\u044f-\u043a\u043b\u0456\u0442\u0438\u043d\u043d\u0438\u043c\u0438-\u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u0430\u043c\u0438-\u0449\u043e-\u043a\u0430\u0436\u0443\u0442\u044c-\u0434\u043e\u0441\u043b\u0456\u0434\u0436\u0435\u043d\u043d\u044f\" class=\"wp-block-heading\"><a href=\"https:\/\/coolaser.clinic\/en\/news\/psoriasis-stem-cell-treatment\/\">Psoriasis: treatment with cellular preparations<\/a><\/h2>\n<p>Stem cell therapy is a new and promising technique that can have a significant impact on the treatment of psoriasis. Stem cells have unique properties that allow them to:<\/p>\n<ul>\n<li>Repair damaged tissue<\/li>\n<\/ul>\n<p>Stem cells can differentiate into different types of cells, which helps restore normal skin structure. This is especially important for patients with severe psoriasis who experience significant skin damage.<\/p>\n<ul>\n<li>Modulation of the immune response<\/li>\n<\/ul>\n<p>Stem cells can influence the immune system, reducing inflammatory reactions and improving skin condition. They are able to regulate the activity of T-lymphocytes and other cells of the immune system, which can lead to long-term remission.<\/p>\n<p>Scientific studies show encouraging results for the use of stem cells in the treatment of psoriasis. Although this therapy is still being studied, the first clinical trials indicate its effectiveness and safety.<\/p>\n<h3><strong>The process of stem cell treatment<\/strong><\/h3>\n<p>Stem cell treatment includes the following stages:<\/p>\n<ol>\n<li aria-level=\"1\">Cell collection: stem cells can be obtained from bone marrow, adipose tissue or umbilical cord blood.<\/li>\n<li aria-level=\"1\">Cell processing: The cells are processed and prepared for injection.<\/li>\n<li aria-level=\"1\">Cell injection: the cells are administered to the patient by injection.<\/li>\n<\/ol>\n<p>The treatment process requires careful monitoring and control by doctors.<\/p>\n<p>Immunobiological therapy for psoriasis and stem cell therapy for psoriasis are modern and effective treatments that can significantly improve the quality of life of patients. These methods help to reduce the manifestations of the disease by reducing inflammation and improving skin condition.<\/p>\n<p>It is important to remember that the choice of appropriate treatment should be based on the patient&#8217;s individual characteristics and the severity of the disease. Before starting treatment, be sure to consult with your doctor to determine the best treatment plan for your needs.<\/p>\n<h2>Treatment <b>recommendations<\/b><\/h2>\n<ul>\n<li aria-level=\"1\">Regular consultations with your doctor: to monitor your condition and adjust treatment.<\/li>\n<li aria-level=\"1\">Compliance with your doctor&#8217;s prescriptions: it is important to follow the recommendations for the use of medications exactly.<\/li>\n<li aria-level=\"1\">Maintaining a healthy lifestyle: proper nutrition, avoiding bad habits, and moderate exercise can help improve your health.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Immunobiological Therapy of Psoriasis and Stem Cell Treatment: A Complete Overview Psoriasis is a chronic inflammatory skin disease that affects [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[48],"tags":[],"class_list":["post-1082","post","type-post","status-publish","format-standard","hentry","category-psoriasis-us"],"featured_image_src":null,"author_info":{"display_name":"\u0417\u0456\u043d\u0435\u043d\u043a\u043e \u041e\u043b\u0435\u0441\u044f \u0412\u0430\u0441\u0438\u043b\u0456\u0432\u043d\u0430","author_link":"https:\/\/www.derm.com.ua\/en\/author\/zinenko\/"},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v24.2 (Yoast SEO v26.9) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Immunobiologic therapy for psoriasis<\/title>\n<meta name=\"description\" content=\"The process of developing inflammation in psoriasis Psoriasis occurs due to the improper response of the human immune system to 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